Dosing
Mulpleo is simple to initiate with a once-daily dosing schedule1
- A single 3mg oral tablet, once-daily for 7 days, with or without food1
- Extended procedural window compared to platelet transfusion allows procedures to be performed from day 9 after treatment initiation1
- Platelet count should be measured prior to a procedure1
- No known contraindications to date1
- No drug-drug interactions to date1,2
7 DAYS
Simple once-daily dosing with or without food1
WAIT 2 DAYS
Until Day 91
DAY 9 ONWARDS
Extended procedural window compared to platelet transfusion3
Recommendations for Mulpleo in special populations:1
No dosage adjustment is necessary in patients 65 years of age or older
No dosage adjustment is necessary in patients with renal impairment
No dosage adjustment is necessary in patients with severe hepatic impairment. Platelet count should be measured at least once approximately 5 days after the first dose, and as necessary thereafter
-
There is limited information on the use of Mulpleo in patients with severe (Child-Pugh class C) hepatic impairment. Mulpleo should only be used in such patients if the expected benefit outweighs the expected risks. Although no dose adjustment is required in these subjects, platelet count should be measured at least once approximately 5 days after the first dose, and as necessary thereafter. Please refer to the Mulpleo SmPC for full safety data.1
Help support your patients in the appropriate use of Mulpleo using our specially designed patient resources
References
Mulpleo (lusutrombopag) Summary of Product Characteristics
Katsube T, Inoue Y, Fukuhara T, et al. Eur J Clin Pharmacol. 2020;76:1659–1665.
Brown RS, Imawar M, Izumi N, et al. JHEP Rep. 2021;3(2):100228.